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According to the regulatory guidelines, it is also pinpointed that development should consider immunogenicity and impairment of organs, including renal and hepatic function, which may affect drug metabolism and safety

McMahon M, Thomas N, Itoh K, Yamamoto M, Hayes JD

The initial stages of individual aging are also closely linked to vascular endothelial senescence (Brandes Ralf et al., 2005)

If you do have decreased kidney function and your doctor recommends methylcobalamin, you may need a much higher dose because its less stable, so be sure to ask them about whats best given your condition

01 Measure In-depth diagnostic testing and baseline labs before any plan begins